Contribution of asparagine residues to the stabilization of an antigen-antibody complex, HyHEL-10-hen egg white lysozyme
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چکیده
Akiko YOKOTA, Kouhei TSUMOTO, Mitsunori SHIROISHI, Takeshi NAKANISHI, Hidemasa KONDO and Izumi KUMAGAI* 1 Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Aoba-yama 6-6-11, Aoba-ku, Sendai 980-8579, Japan 2 Research Institute of Genome-based Biofactory, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8517, Japan
منابع مشابه
Association and dissociation kinetics of bobwhite quail lysozyme with monoclonal antibody HyHEL-5.
The anti-hen egg lysozyme monoclonal antibody HyHEL-5 and its complexes with various species-variant and mutant lysozymes have been the subject of considerable experimental and theoretical investigation. The affinity of HyHEL-5 for bobwhite quail lysozyme (BWQL) is over 1000-fold lower than its affinity for the original antigen, hen egg lysozyme (HEL). This difference is believed to arise almos...
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تاریخ انتشار 2013